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For infiltration or regional anesthesia, use 0.5-2% solutions in dosage of 3.5-mg/kg-body weight in healthy individuals. Without epinephrine, total dose should not exceed 300 mg (15 mL). With epinephrine, total dose should not exceed 500 mg (25 mL).
For topical mucosal anesthesia, use 1.2% solution to be applied by means of spray, cotton pledges, or applicators.
It is difficult to recommend a maximum dose of a drug for children since this varies as a function of age and weight. The maximum dose may be computed for children of less than ten and who have a normal lean body mass and normal development, by the application of one of the standard pediatric formulas (e.g. Clark's rule or Young's rule).
